Malaria, a life-threatening disease caused by Plasmodium parasites transmitted through the bites of infected mosquitoes, poses a significant challenge to healthcare systems worldwide. Its management becomes even more complex when a patient has an autoimmune condition like rheumatoid arthritis or lupus. These autoimmune diseases involve the immune system mistakenly attacking the body’s own tissues, leading to chronic inflammation and tissue damage. The treatment for these conditions often involves immunosuppressive drugs, which can increase susceptibility to infections, including malaria.