Studies suggest that vardenafil can remain effective and well‑tolerated over extended periods (e.g., 1–2 years), with many men maintaining improved erectile function without new safety concerns when used as directed. This supports its use for long‑term ED management under medical supervision.Taking a high dose like 40 mg regularly should only be done under a doctor’s guidance, especially if you have heart disease, liver/kidney issues, blood pressure problems, or are on interacting medications.