Statistics of antimicrobial resistance in Nigeria reveal a growing public health concern. Recent data highlights alarming resistance levels among common pathogens like E. coli and Staphylococcus aureus, significantly reducing the effectiveness of widely used antibiotics. Studies from 2024–2025 show over 70% resistance in some hospital-acquired infections, especially in tertiary healthcare centers. These statistics of antimicrobial resistance in Nigeria emphasize the urgent need for nationwide surveillance, antibiotic stewardship, and public awareness programs. Without coordinated interventions, resistant infections may lead to higher treatment costs, prolonged hospital stays, and increased mortality, posing a severe threat to the Nigerian healthcare system and its population.