[How Long Does It Take for Ambien to Work]https://fairlawnfamilydentist.com/order-ambien.php)? Ambien (zolpidem) typically starts working within 15 to 30 minutes after taking it. It is a fast-acting sleep medication prescribed to treat insomnia and is most effective when taken right before bedtime. For best results, take Ambien on an empty stomach and ensure you are ready to sleep for at least 7 to 8 hours. Avoid activities like driving or using machinery after taking Ambien, as it can cause drowsiness quickly.