Praziquantel is the primary medication used to treat schistosomiasis, a parasitic infection caused by blood flukes of the genus Schistosoma. The infection typically occurs in tropical and subtropical regions, especially in areas with poor sanitation and contaminated freshwater sources. Schistosomiasis can lead to chronic health issues such as liver, intestinal, bladder, or urogenital damage, depending on the species involved.
Praziquantel works by increasing the permeability of the parasite’s cell membranes to calcium, leading to paralysis and death of the worms. This process helps the body’s immune system to eliminate the parasites. It is effective against all major Schistosoma species, including S. haematobium, S. mansoni, and S. japonicum. Buy Praziquantel Wholesale Online at top pharmacy Medzsupplier.
The standard dosage of Praziquantel for schistosomiasis in adults and children is typically 40–60 mg/kg body weight, administered in one or two divided doses in a single day. The drug is generally well tolerated, though mild side effects such as abdominal discomfort, dizziness, nausea, headache, or fatigue may occur.
Praziquantel is recommended by the World Health Organization (WHO) for preventive chemotherapy programs in endemic regions, aiming to reduce the disease burden, especially among school-age children. Periodic mass drug administration (MDA) has proven successful in lowering transmission rates and preventing long-term complications.
Early diagnosis and treatment with Praziquantel are essential to avoid the chronic and sometimes irreversible consequences of schistosomiasis. In areas with continued exposure to infested water, repeated treatment may be necessary. Although Praziquantel does not prevent reinfection, its use remains the cornerstone of schistosomiasis control and elimination efforts globally.