Menopause introduces numerous changes, and one of the less frequently addressed consequences is its effect on inflammation and immunity. As estrogen levels decrease, the body loses a vital protective hormone that aids immune cell function and mitigates inflammatory responses. This hormonal alteration may result in more frequent infections, prolonged healing times, fatigue, joint pain, and heightened sensitivity to common triggers. In addition to lifestyle factors such as sleep quality, stress management, and nutrition, the changes associated with menopause can affect overall immunity and inflammation. With appropriate support—such as a diet rich in antioxidants, omega-3 fatty acids, balanced nutrition, and regular physical activity—women can achieve improved immune balance and enhance their well-being during this transitional phase.