Menopause represents a natural biological transition characterized by alterations in estrogen and progesterone levels. These hormonal changes significantly impact the functioning of the immune system and the body's regulation of inflammation. Studies indicate that the reduction of estrogen levels during menopause may affect immune equilibrium, occasionally resulting in modifications to inflammatory responses. This can have implications for overall health, recovery from illnesses, and the body's reaction to both physical and emotional stress. Gaining insight into the connection between menopause and immunity enables women to make educated lifestyle and wellness decisions during their midlife years.