Unlike successful RA modeling in rodents, NHP RA model has been reported to be extremely difficult due to the low and inconsistent disease incidence in both cynomolgus macaques and rhesus macaques. After years of exploration, scientists in Creative Biolabs now can successfully induce RA in cynomolgus monkeys using type II collagen. This well-characterized NHP arthritis model has proved good utility in rheumatology studies, inflammation related anemia and pain studies.