pMHC microarrays are innovative platforms designed to analyze peptide-MHC interactions at high throughput. They facilitate the screening of epitopes and assessment of T cell responses, thus enhancing our understanding of immune recognition. This technology supports the development of targeted immunotherapies and personalized vaccines by enabling precise mapping of antigenic determinants. Researchers utilize pMHC microarrays to accelerate the identification of effective therapeutic targets in cancer and infectious diseases.