Phospholipid micelles are nanocarriers designed for drug delivery, formed by the self-assembly of phospholipids in aqueous environments. These structures feature a hydrophobic core and a hydrophilic outer layer, enhancing the solubility and bioavailability of poorly soluble drugs. Their small size allows for prolonged circulation and targeted delivery, reducing off-target effects. Phospholipid micelles are widely applied in cancer therapy, neurodegenerative disease treatment, and polynucleotide therapeutics, offering a promising approach for advanced drug formulations.